Julien H . Arrizabalaga and Jaclyn A . Brennan

نویسندگان

  • Julien H. Arrizabalaga
  • Jaclyn A. Brennan
  • Jorge Baez
  • Hiba Baroud
  • Carter Browning
چکیده

Coronary heart disease is the leading cause of death in the United States. An alternate therapy is needed to treat the 180,000 people each year who require coronary artery bypass surgery. Several different strategies have been explored to develop vascular graft substitutes, but so far all have proven unsatisfactory. Current engineered vessels lack sufficient strength or require many weeks to be fully functional. We propose an innovative solution using patient-derived stem cells obtained from fat tissue. Cells will be seeded onto a biological collagen sheet derived from the human placenta, and rolled into a tube with appropriate diameter. The tubular construct will be mounted in a perfused bioreactor to simulate the mechanical conditions of native vessels. This project has the potential to provide off-theshelf availability of replacement blood vessels.

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تاریخ انتشار 2012